Table 2.
Discrimination of total prostate-specific antigen
| High-grade cancer | Any-grade cancer | |
|---|---|---|
| Age and PSA* | 0.719 (0.672–0.767) | 0.632 (0.590–0.674) |
| Age, four-kallikrein panel | 0.777 (0.736–0.819) | 0.683 (0.644–0.722) |
| Age, PSA, DRE* | 0.736 (0.689–0.782) | 0.638 (0.597–0.679) |
| Age, four-kallikrein panel, and DRE | 0.784 (0.742–0.826) | 0.690 (0.652–0.729) |
AUC = area under the curve; DRE = digital rectal examination; PSA = prostate-specific antigen.
Data are shown as AUC (95% confidence interval). This risk model incorporates age and total PSA, a previously specified model using age and a panel of four kallikrein markers, and a second previously specified model using age, a panel of four kallikrein markers, and digital rectal examination.
AUC was corrected for overfit using 10-fold cross validation.