Table 4.

Marginal discrimination of each of the four kallikrein markers

	Age and kallikreins	Age, kallikreins, and DRE
High-grade cancer
Full model	0.777 (0.736–0.819)	0.784 (0.742–0.826)
Without total PSA	0.628 (0.577–0.678)	0.685 (0.637–0.733)
Without free PSA	0.612 (0.562–0.662)	0.628 (0.578–0.679)
Without intact PSA	0.740 (0.695–0.785)	0.759 (0.716–0.803)
Without hK2	0.770 (0.728–0.811)	0.782 (0.741–0.823)
Without intact PSA nor hK2	0.704 (0.656–0.752)	0.732 (0.686–0.778)
Any-grade cancer
Full model	0.683 (0.644–0.722)	0.690 (0.652–0.729)
Without total PSA	0.572 (0.529–0.614)	0.608 (0.567–0.650)
Without free PSA	0.638 (0.597–0.679)	0.647 (0.607–0.688)
Without intact PSA	0.682 (0.643–0.722)	0.690 (0.651–0.728)
Without hK2	0.649 (0.608–0.689)	0.665 (0.625–0.705)
Without intact PSA nor hK2	0.648 (0.607–0.688)	0.664 (0.624–0.704)

DRE = digital rectal examination; hK2 = human kallikrein-related peptidase 2; PSA = prostate-specific antigen.

Data are shown as area under the curve (95% confidence interval).