Table 2.

The most parsimonious models for the multiple regression of normalized AKR7A2mRNA expression including methylation sites in heart samples from donors without (top) and with DS (bottom). This model was obtained from a full model containing five candidate methylation sites, and reduced using a drop-one approach until only significant factors remained. The columns represent the coefficients, standard error of the coefficient estimates, t-test and p-values from the hypothesis test on the coefficients.

Non-DS
Term	β-estimate	Std. Error	t-stat	P-Value
(Intercept)	4.697	1.011	4.648	0.000315
CpG−865	−5.813	2.019	−2.879	0.011476*
DS
Term	β-estimate	Std. Error	t-stat	P-Value
(Intercept)	−1.0870	0.6712	−1.620	0.15645
CpG−232	9.3224	2.3862	3.907	0.00792*