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Caveats of tumor cellularity estimation. Number of nuclei rather than surface area of nuclei or entire cells should dictate % tumor cellularity estimates (a). This may be difficult for human “eyeball” estimates—here, tumor cellularity is estimated at 50 % according to surface area, but the mutant allele (assuming heterozygosity) is 20 %. Nuclear truncation in tissue section also leads to overestimated tumor contents (b)
