Table 5.

Association results for low-frequency and rare SCARB1 variants (MAF <5 %)

MAF	No of Variants	No of Samples with/without Variants	HDL-C		ApoA-I
			Stat	P	Stat	P
≤0.01	23a	93/694	126653.8207	0.0478	60151.0985	0.3707
≤0.02	26	134/653	123009.0805	0.1324	48439.6697	0.5166
<0.05	43	442/346	135697.1974	0.0737	298813.0544	0.1517

ApoA-I apolipoprotein A-I, HDL-C high-density lipoprotein cholesterol, MAF minor allele frequency, SD standard deviation, SNP single nucleotide polymorphism

Results were adjusted for covariates: sex, age, waist, current smoking (yes/no), and minutes of walking or biking to work each day (jobmin) for HDL-C; sex and age for ApoA-I

Nominally significant P-values (P < 0.05) are shown in bold

^aIncluding p70201/chr12:125279319 that was observed in one individual with an outlier value (above the mean + 3.5 SD). See details in Result Section 3.5