Table 4.
Clinical-pathological characteristics associated with gene carrier status*
| Characteristic | Carrier status | BARD1 | BRIP1 | NBN | PALB2 |
|---|---|---|---|---|---|
| No. (%) | No. (%) | No. (%) | No. (%) | ||
| Age at diagnosis, y | |||||
| <40 | Carrier | 1 (25.0) | 0 (0) | 0 (0) | 1 (11.1) |
| Noncarrier | 148 (4.5) | 149 (4.6) | 149 (4.6) | 149 (0.4) | |
| 40–59 | Carrier | 0 (0) | 2 (6.7) | 2 (22.2) | 3 (33.3) |
| Noncarrier | 460 (14.1) | 458 (14.2) | 458 (14.2) | 457 (14.1) | |
| 50–59 | Carrier | 3 (75.0) | 9 (30.0) | 3 (33.3) | 1 (11.1) |
| Noncarrier | 977 (30.0) | 971 (30.1) | 977 (30.1) | 979 (30.1) | |
| ≥60 | Carrier | 0 (0) | 19 (63.3) | 4 (44.4) | 4 (44.4) |
| Noncarrier | 1662 (51.0) | 1643 (50.1) | 1658 (51.0) | 1658 (51.0) | |
| Tumor subtype | |||||
| High-grade serous | Carrier | 3 (75.0) | 25 (83.3) | 6 (66.7) | 6 (66.7) |
| Noncarrier | 2279 (70.0) | 2257 (70.0) | 2276 (70.0) | 2276 (70.0) | |
| Other | Carrier | 1 (25.0) | 5 (16.7) | 3 (33.3) | 3 (33.3) |
| Noncarrier | 974 (30.0) | 970 (30.0) | 972 (30.0) | 972 (30.0) | |
| Family history | |||||
| OvCa family history | Carrier | 0 (0) | 2 (6.7) | 0 (0) | 2 (22.2) |
| Noncarrier | 275 (8.4) | 273 (8.4) | 275 (8.5) | 273 (8.4) | |
| BrCa family history | Carrier | 0 (0) | 3 (10.0) | 1 (11.1) | 1 (11.1) |
| Noncarrier | 427 (13.1) | 424 (13.1) | 426 (13.1) | 426 (13.1) | |
| Ov/BrCa family history | Carrier | 0 (0) | 4 (13.3) | 1 (11.1) | 2 (22.2) |
| Noncarrier | 612 (18.8) | 608 (18.8) | 611 (18.8) | 610 (18.8) |
* Other epithelial invasive ovarian cancer subtypes specified: clear cell, endometriosis, mucinous, and mixed. BrCa = breast cancer; OvCa = ovarian cancer.