Table 5.
Mutation frequency by family history in UCKFOCSS subjects*
| Family history | Carrier status | BARD1 | BRIP1 | NBN | PALB2 |
|---|---|---|---|---|---|
| No. (%) | No. (%) | No. (%) | No. (%) | ||
| 1 ovarian cancer, ≤2 breast cancer case (age <60 y) | Carrier | 1 (33.3) | 5 (41.7) | 2 (66.7) | 4 (57.1) |
| Noncarrier | 1087 (56.4) | 1083 (56.4) | 1086 (54.3) | 1084 (56.3) | |
| 2 ovarian cancer | Carrier | 1 (33.3) | 6 (50.0) | 0 (0) | 1 (14.3) |
| Noncarrier | 558 (28.9) | 553 (28.7) | 559 (29.0) | 559 (29.0) | |
| Other related cancers in extended family | Carrier | 1 (33.3) | 1 (8.3) | 1 (33.3) | 2 (28.6) |
| Noncarrier | 283 (14.7) | 283 (14.7) | 283 (14.7) | 282 (14.6) |
* Thirty individuals with one ovarian cancer and three colorectal cancers (1 age <50 y) in primary relatives and 39 individuals with three or more breast cancers had no carriers detected for any gene. UKFOCSS = United Kingdom Familial Ovarian Cancer Screening Study.