Skip to main content
. Author manuscript; available in PMC: 2016 Oct 2.
Published in final edited form as: ACS Catal. 2015 Sep 2;5(10):6061–6068. doi: 10.1021/acscatal.5b01332

Table 1.

Isotope effects on the activation energy (ΔEa,T/H) and the Arrhenius pre-exponential factor (AH/AT) for the proton abstraction (PA) and the hydride transfer (HT) in the WT and R166K.

ΔEa,T/H (kcal/mol) AH/AT
PA (WT)16 8.0 (±0.16) 8.3 (±1.0) × 10−6
PA (R166K) 9.0 (±0.10) 3.30 (±1.4) × 10−6
HT (WT)15 0.02 (±0.25) 6.8 (±2.80)
HT (R166K)42 3.62 (±0.02) 0.023 (±0.003)