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. Author manuscript; available in PMC: 2016 Feb 1.
Published in final edited form as: Trends Pharmacol Sci. 2015 Jan 27;36(2):72–77. doi: 10.1016/j.tips.2014.12.004

Figure 4. List of representative factors that can modulate protein aggregation.

Figure 4

Since the concentrations of proteins in the cellular environment should be maintained below the critical levels, a wide range of quality control mechanisms is in place for this purpose (green side). A variety of events and processes, however, could shift the balance towards more aggregation-prone conditions (red side). A general goal of pharmacological interventions against neurodegenerative diseases should be a reduction of the driving force for protein aggregation by suppressing protein supersaturation.