Table 4.
Percent attenuation of the associations of age and BMI with VTE by CRP and serum albumin
| Inflammation Biomarker | Age HR (95% CI) | BMI HR (95% CI) |
|---|---|---|
| Model 1 | 1.55 (1.36, 1.76) | 1.33 (1.18, 1.50) |
| Model 1 + lnCRP | 1.54 (1.19, 2.0) | 1.26 (1.23, 2.08) |
| Model 1 + Albumin | 1.57 (1.33, 1.85) | 1.19 (1.01, 1.40) |
| Change in HR (%) | ||
| CRP | 1.8% (−9.1%, 9.1%) | 21.2% (2.7%, 36.4%) |
| Albumin | 3.6% (−21.8%, 32.7%) | 42.4% (6.1%, 81.8%) |
| Model 2 | 1.70 (1.47, 1.96) | 1.39 (1.23, 1.58) |
| Model 2 + lnCRP | 1.68 (1.45, 1.95) | 1.33 (1.16, 1.52) |
| Model 2 + Albumin | 1.66 (1.39, 1.99) | 1.23 (1.04, 1.46) |
| Change in HR (%) | ||
| CRP | 2.9% (−4.3%, 8.6%) | 15.4% (7.7%, 33.3%) |
| Albumin | 5.7% (−20.0%, 30.0%) | 41.0% (12.8%, 79.5%) |
Age and BMI were modeled per standard deviation (SD) higher (Age SD= 10 years; BMI SD= 6.2 kg/m2).
Model 1: Age, sex, race, region, race*region interaction.
Model 2: Model 1 + BMI, diabetes, smoking status, hypertension, and history of coronary heart disease or stroke.