Fig 8. O-GlcNAc-primed CSCs maintain a normal growth profile, but loss of Ogt suppresses proliferation.

A: Growth curves of CSCs maintained in culture with TMG demonstrate that augmented O-GlcNAc levels do not affect the characteristics of normal population growth. B: Ogt deletion results in significantly reduced cell proliferation. Inset indicates loss of OGT protein and diminished O-GlcNAc levels in the OGT KO cells. n = 3/group, *p < 0.05 vs OGT FL.