Table 2. Metabolites in NAWM and lesion load in the visual pathways in MS patients.
| Metabolites in NAWM | lesion volume in visual pathway | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | N = | f:m | age | disease | Cho | Cr[mM] | NAA[mM] | AD/ | AS/ | PD/ | PS/ | Total |
| duration | [mM] | [mM] | [mM] | Volume | Volume | Volume | Volume | Lesion/ | ||||
| Volume | ||||||||||||
| RRMS | 17 | 11:6 | 39.75 | 8.1 | 2.5 | 8.3 | 11.3 | 0.04 | 0.05 | 0.48 | 0.46 | 1.03 |
| without ON | ||||||||||||
| STE | ± 2.5 | ± 2.5 | ± 0.10 | ± 0.30 | ± 0.60 | ± 0.02 | ± 0.02 | ± 0.09 | ± 0.08 | ± 0.2 | ||
| range | 19.75–61.0 | 1.0–45.0 | 1.47–3.15 | 4.72–10.55 | 4.86–14.08 | 0.00–0.28 | 0.00–0.23 | 0.01–1.39 | 0.02–1.22 | 0.03–2.71 | ||
| RRMS | 6 | 5:1 | 36.5 | 13.6 | 2.4 | 8.4 | 11.9 | 0.10 | 0.13 | 0.90 | 0.78 | 1.91 |
| with ON | ||||||||||||
| STE | ± 4.0 | ± 4.3 | ± 0.07 | ± 0.44 | ± 1.09 | ± 0.06 | ± 0.05 | ± 0.20 | ± 0.23 | ± 0.51 | ||
| range | 19.75–47.5 | 2.0–27.5 | 2.11–2.58 | 6.48–9.48 | 7.67–14.95 | 0.00–0.33 | 0.00–0.28 | 0.19–1.48 | 0.10–1.47 | 0.32–3.54 | ||
| SPMS | 2 | 1:1 | 36.75 | 10.25 | 2.2 | 7.4 | 9.9 | 0.30 | 0.33 | 1.58 | 0.96 | 3.17 |
| without ON | ||||||||||||
| STE | ± 9.75 | ± 3.75 | ± 0.28 | ± 0.45 | ± 0.73 | ± 0.10 | ± 0.10 | ± 0.54 | ± 0.06 | ± 0.80 | ||
| range | 27.0; 46.5 | 6.5; 14.0 | 1.91–2.48 | 6.91–7.81 | 9.14–10.59 | 0.20–0.40 | 0.23–0.42 | 1.04–2.12 | 0.90–1.02 | 2.37; 3.54 | ||
| SPMS with ON | 3 | 1:2 | 40.75 | 19.75 | 2.55 | 8.4 | 9.6 | 0.31 | 0.15 | 1.24 | 0.95 | 2.65 |
| with ON | ||||||||||||
| STE | ± 5.2 | ± 5.9 | ± 0.11 | ± 0.21 | ± 0.81 | ± 0.13 | ± 0.06 | ± 0.23 | ± 0.34 | ± 0.69 | ||
| range | 30.5–47.5 | 8.5–28.3 | 2.40–2.76 | 8.11–8.77 | 8.25–11.07 | 0.05–0.49 | 0.04–0.24 | 0.78–1.48 | 0.48–1.60 | 1.36–3.70 | ||
Metabolites, N-Acetyl-Aspartate (NAA), Choline (Cho) and creatine (Cr) given in mM; lesion load in the visual pathways, here given as ratio of lesion volume in the visual pathways (AD, right anterior; AS, left anterior; PD, right posterior; PS, left posterior and total lesion volume) to total brain volume.