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. 2015 Nov 13;10(11):e0142272. doi: 10.1371/journal.pone.0142272

Table 3. Brain atrophy indices in MS patients.

Group N = f:m age disease Evans CHI CMI BCI maximum maximum MFSS MIF MSF
width width
duration ratio of 3rd of 4th
ventricle ventricle
RRMS 17 11:6 39.75 8.1 0.26 0.12 0.19 0.22 5.5 11.2 2.5 2.4 2.0
without ON
STE ± 2.5 ± 2.5 ± 0.1 ± 0.1 ± 0.2 ± 0.005 ± 0.73 ± 0.37 ± 0.2 ± 0.2 ± 0.2
range 19.75–61.0 1.0–45.0 0.17–0.34 0.05–0.21 0.1–0.33 0.17–0.25 1.5–11.1 9.3–14.0 1.0–4.1 1.5–4.3 1.0–5.0
RRMS 6 5:1 36.5 13.6 0.23 0.08 0.12 0.22 3.6 10.8 3.1 2.5 2.2
with ON
STE ± 4.0 ± 4.3 ± 0.1 ± 0.1 ± 0.2 ± 0.01 ± 0.59 ± 0.96 ± 0.4 ± 0.3 ± 0.5
range 19.75–47.5 2.0–27.5 0.21–0.25 0.05–0.12 0.07–0.21 0.19–0.24 1.7–5.2 7.3–13.5 2.0–4.0 1.3–3.4 1.0–4.0
SPMS 2 1:1 36.75 10.25 0.26 0.12 0.25 0.26 7.3 10.3 3.40 3.8 2.8
without ON
STE ± 9.75 ± 3.75 ± 0.1 ± 0.2 ± 0.2 ± 0.04 ± 1.4 ± 0.3 ± 0.7 ± 0.5 ± 0.8
range 27.0; 46.5 6.5; 14.0 0.25–0.27 0.10–0.13 0.23–0.27 0.22–0.31 5.9–8.7 10.0–10.6 2.7–4.1 3.3–4.3 2.0–3.6
SPMS 3 1:2 40.75 19.75 0.23 0.10 0.16 0.19 5.5 11.4 2.8 1.9 2.3
with ON
STE ± 5.2 ± 5.9 ± 0.2 ± 0.1 ± 0.2 ± 0.02 ± 1.72 ± 1.0 ± 0.1 ± 0.4 ± 0.5
range 30.5–47.5 8.5–28.3 0.20–0.25 0.08–0.12 0.12–0.19 0.16–0.22 3.6–8.9 9.4–12.7 2.7–3.0 1.2–2.5 1.4–2.8

CHI, the caudate head index; BCI, the basal cistern index; CMI, the cella media index; MIF, the maximum width of the anterior interhemispheric fissure; MSF, the maximum width of the Sylvian fissure; and MFSS, the maximum frontal subarachnoid space.