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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2015 Apr 16;25(11):2261–2268. doi: 10.1016/j.bmcl.2015.04.019

Figure 2.

Figure 2

Crystal structures of A) the E79TGE82 motif of Nrf2 complexed with Keap1 (PDB ID 2FLU)a; B) the E79NGE82 motif of ProTα (PDB ID 2Z32)a; C) the DLG motif of Nrf2 (PDB ID 3WN7)a; D) the KIR region of p62 (3ADE)a; E) the phosphorylated KIR region of p62 (PDB ID 3WDZ)a; F) tetrahydroisoquinoline 4 (PDB ID 4L7B); G) naphthalene 7 (PDB ID 4IQK); H) thiopyrimidine 6 (PDB ID 4IN4); I) urea 10 (PDB ID 3VNH); J) binding pocket of the Kelch domain of Keap1 with the naphthalene ligand 7 removed, demonstrating the five subpockets P1-P5 of the Kelch domain (PDB ID 4IQK).

aThe remainder of the residues have been removed for clarity.