Table 4. Association of haplotypes constructed from rs7249246 and rs12609735 in CACNA1A.

Marker	Haplotypes	freq	Fam	S	E (S)	Var (S)	Z	p	Global p	Permutationa p
rs7249246- rs12609735	G-T	0.456	355.0	352.30	367.42	112.48	-1.422	0.155	0.210	0.187
	T-C	0.299	299.8	262.30	246.92	100.15	1.541	0.123
	T-T	0.200	285.7	191.70	197.58	82.23	-0.652	0.514
	G-C	0.045	85.5	51.70	46.08	18.90	1.284	0.199

^a Whole marker permutation test using chisq sum p value, the number of permutation is 10,000; freq, Estimation of haplotype frequencies; Fam, number of informative families; S, test statistics for the observed number of transmitted alleles; E(S), expected value of S under the null hypothesis (i.e., no linkage and no association).