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Uridine could induce neurite outgrowth associated with expression of neuronal differentiation marker (GAP-43, tubA4a, and tubB1). Uridine stimulated CREB phosphorylation and neurite outgrowth mainly through activation of P2Y-dependent pathway. MEK/ERK1/2 and PI3K/Akt/mTOR were also partly involved in the uridine-induced neurite outgrowth. ↑ = increase.
