Table 1. Apoptosis induced by Jo2.
%AnnexinV/CD44hi/CD8+ | IgG | Jo2 |
WT Day 0 p.i. | 33.74±2.16 | 34.14±2.45 |
KO Day 0 p.i. | 37.54±3.74 | 38.77±3.56 |
WT Day 2 p.i. | 38.37±1.58 | 48.35±1.83* |
KO Day 2 p.i. | 51.82±0.74** | 60.17±1.26* , ** |
%AnnexinV/CD44hi/CD4+ | IgG | Jo2 |
WT Day 0 p.i. | 52.46±2.31 | 63.7±1.28* |
KO Day 0 p.i. | 57.26±2.46 | 67.43±1.33*, ** |
WT Day 2 p.i. | 60.37±1.39 | 69.27±0.84* |
KO Day 2 p.i. | 68.37±0.8** | 74.45±1.05* , ** |
This table represents the percentage of AnnexinV+ WT and KO CD44hiCD8 and CD44hiCD4 cells after culturing the splenocytes of naïve (day 0) or day 2 p.i. chimaeric mice in the presence of either IgG control or the Fas agonist Jo2 for 16 hours. (n = 4 mice per timepoint, ± = SEM).
*p ≤ 0.05 between IgG and Jo2 conditions
**p ≤ 0.05 between WT and KO under the IgG or Jo2 condition