Table 1. Hemodynamic measurements from wildtype (WT) and CREBA133 mice during cardiac echocardiography.
| FAC (%) | FS (%) | LVEF (%) | SV (mL/mg) | CO (mL/min/mg) | LVIDd(mm) | LVIDs (mm) | |
|---|---|---|---|---|---|---|---|
| Wildtype (n = 7) | 50.2 ± 2.96 | 32.6 ± 1.56 | 63.4 ± 1.36 | 2.03 ± 0.26 | 952 ± 123 | 4.1 ± 0.21 | 2.8 ± 0.20 |
| Early HF CREBA133 (n = 8) | 32.54 ± 3.46 *** | 23.9 ± 2.09 ### | 47.7 ± 3.61 ***/### | 1.65 ± 0.20 | 722 ± 81 | 4.4 ± 0.07 ### | 3.4 ± 0.12 ***/### |
| Acute HF CREBA133 (n = 8) | 20.6 ± 3.01 *** | 14.4 ± 1.181 *** | 30.2 ± 2.24 *** | 1.55 ± 0.37 | 434 ± 57 ** | 5.4 ± 0.14 *** | 4.6 ± 0.1 *** |
| Chronic HF CREBA133 (n = 9) | 36.6 ± 5.03 ### | 24.2 ± 2.82 ### | 47.1 ± 4.73 ***/### | 1.4 ± 0.18 | 590 ± 58 ** | 4.9 ± 0.19 *** | 3.9 ± 0.13 *** /### |
Fractional area change (FAC); fractional shortening (FS); left ventricular ejection fraction (LVEF); stroke volume (SV); cardiac output (CO); LV diastolic (d) and systolic (s) internal diameter (LVID).
*p<0.05 vs WT,
**p<0.01 vs WT,
***p<0.001 vs WT,
#p<0.05 vs Acute HF,
##p<0.01 vs Acute HF,
###p<0.001 vs Acute HF.