Figure 1.
An unidentified 5-HT current in prefrontal cortex of rat and mouse: evidence of functional 5-HT5A receptors. In the rat (A1) and mouse (B1) prefrontal cortex, bath application of 5-HT (10 μm; 30 s) elicits an unidentified outward current in the presence of the 5-HT1A and 5-HT2 antagonists, WAY-100635 (WAY) and ketanserin (Ket). The bar graphs summarize within-cell paired experiments from rats (A2) and mice (B2), showing that the baseline unidentified 5-HT current is a postsynaptic current that does not change in the presence of TTX but is significantly suppressed by the 5-HT5A antagonist, SB-699551 (SB) (repeated-measures ANOVA; rat, ***p = 0.0001; mouse, ***p < 0.0001).