Figure 3.

Characterization of the 5-HT_5A current in the normal adult rodent cortex. A, Current-clamp trace illustrates that the 5-HT_5A current can inhibit neuronal excitability resulting from a constant depolarizing current. B, The concentration–response curves demonstrate that the 5-HT_5A receptor has relatively high affinity for applied 5-HT in both the rat and mouse prefrontal cortex. C, Current–voltage graph illustrates that the 5-HT_5A response is inwardly rectifying and reverses near the calculated equilibrium potential for K⁺ ions. D, Bar graph shows that the 5-HT_5A current is suppressed by the Kir3 channel blockers: Ba²⁺ ions (paired t test; **p = 0.002) and Tertiapin-Q (paired t test; ***p = 0.001). WAY: WAY-100635; Ket: ketanserin.