Table 2.
Clinical Features, Imaging, Treatment and Outcome of PCNSTLs
| Final No. | Age | Sex | Clinical presentation | Imaging | Treatment | Outcome |
|---|---|---|---|---|---|---|
| 1 | 21 | M | Headache | Solitary, right occipital mass (2 cm) | Steroids, Thiotepa+ HD MTX + XRT | na |
| 2 | 61 | M | NA | Solitary frontal mass | na | DOD |
| 3 | 81 | M | NA | Solitary, right occipital mass (2 cm) | Steroids | AwoD (64 mo) |
| 4 | 54 | M | Transient right facial and upper limb sensory symptoms, headaches, facial asymmetry and speech difficulties | Solitary, left frontal mass | HD MTX + XRT | AwD (47 mo) |
| 5 | 60 | M | Headache | Solitary, left cerebellar mass (2.2 cm) | Chemotherapy | DOD (3 mo) |
| 6 | 57 | M | Difficulties short term memory, ataxia, right leg weakness | Multiple lesions throughout the brain, largest left parietal lobe (3.5 cm) | na | na |
| 7 | 69 | M | na | Solitary, right parietal mass | MTX + AraC +Leucovorin + Procarbazine hydrocholoride | AwD |
| 8 | 81 | M | Altered mental status | Right occipital and temporal mass | 2×MTX + bendamustine | AwD (4 mo) |
| 9 | 63 | F | Left sided weakness | Periventricular and striatocapsular abnormalities | no treatment | DOD |
| 10 | 42 | F | Seizures | Right frontal and temporal masses | Dexametasone + HD AraC + 3×MTX + 17 × XRT | AwD (5 mo) |
| 11 | 21 | F | Pregnant, headaches, behavior changes | Solitary parietal mass (7×7×5 cm) | na | na |
| 12 | 67 | F | Aphasia and facial paralysis | Multiple bilateral frontal and occipital masses | 6× HD MTX + XRT | AwoD (56mo) |
| 13 | 31 | M | Seizure and slow (2 yrs) decline in mental function, weight loss, confusion | Bilateral temporal lobes enhancement | na | na |
| 14 | 56 | F | Headache | Solitary right frontal mass | na | na |
| 15 | 57 | M | Progressive neurologic decline | Multiple lesions in the basal ganglia, midbrain, brachium pontis and cerebellar hemispheres | na | DOD |
| 16 | 43 | M | Fever, nausea, vomiting (1 mo) | Multiple meningeal lesions (dural, leptomeningeal, spinal, superficial cortical parietal, right cerebellum and medulla involvement) | na | DOD |
| 17 | 61 | F | Weakness right superior extremity, paresthesia, mild paralysis | Diffuse enhancement | Dexamethasone | DOD (1 mo) |
| 18 | 62 | F | History multiple sclerosis, left lower extremity weakness (3 mo) | Solitary right frontal mass | na | na |
Abbreviations: HD- high dose; XRT- radiation; IT- intrathecal; MTX- Methotrexate; DOD - died of disease, AwoD - alive without disease; AwD - alive with disease; na - not available