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. Author manuscript; available in PMC: 2016 May 12.
Published in final edited form as: Nature. 2015 Oct 14;527(7577):186–191. doi: 10.1038/nature15726

Table 1. Melanoma cells more readily formed tumors upon subcutaneous injection as compared to intravenous or intrasplenic injection.

Limit dilution analysis of data in Extended data figure 3 to infer the minimum frequency of tumor-forming melanoma cells after subcutaneous, intravenous, or intrasplenic transplantation into NSG mice. Each mean value reflects 5 (subcutaneous), 10 (intravenous), or 4 (intrasplenic) independent experiments using melanomas obtained from 8 different patients (see details in Extended data figure 3). Statistical significance was assessed by a chi-square test using the ELDA software46

Melanoma Subcutaneous Intravenous Intrasplenic
Inefficient 1/11 1/2540 graphic file with name nihms724268t1.jpg
# 		1/3677 graphic file with name nihms724268t2.jpg
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Efficient 1/8 1/235 1/173
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p<0.0001.