Extended data table 1.
Fold change and statistical significance corrected for multiple comparisons of metabolites detected by LC-MS/MS in the experiment in Extended data figure 2a.
| Metabolite | Fold Change of Metastasis/SQ Tumor | FDR |
|---|---|---|
| citraconic acid/ketohexanoic acid | 12.311 | 0.054768 |
| glucarate | 11.472 | 0.13347 |
| sedoheptulose 7-phosphate | 5.6121 | 0.084567 |
| GABA | 4.8296 | 0.44062 |
| betaine | 4.8132 | 6.12E-05 |
| AICAR | 4.5004 | 0.15975 |
| carnitine-C18 | 4.4942 | 0.13347 |
| spermidine | 4.4416 | 0.016469 |
| adenosine 5-diphosphoribose | 4.1336 | 0.041494 |
| xanthosine | 3.9645 | 0.11311 |
| glutamine | 3.9371 | 0.000419 |
| hexose-phosphate | 3.0656 | 0.086761 |
| GSSG | 2.8724 | 0.081173 |
| S-methyl-5-thioadenosine | 2.8234 | 0.21534 |
| gluconate | 2.7963 | 0.052588 |
| xanthine | 2.4873 | 0.084567 |
| pyridoxamine | 2.4531 | 0.24821 |
| spermine | 2.3796 | 0.19553 |
| aminoadipic acid | 2.3513 | 0.44062 |
| carnitine-C16 | 2.3105 | 0.27824 |
| uridine | 2.2733 | 0.13025 |
| citrate | 2.1797 | 0.081173 |
| methionine sulfoxide | 2.0674 | 0.22847 |
| ribose 5-phosphate | 2.0193 | 0.40173 |
| glycerol 3-phosphate | 2.0132 | 0.40173 |
| IMP | 1.987 | 0.018053 |
| S-adenosylmethionine | 1.8423 | 0.17083 |
| inosine | 1.8253 | 0.24736 |
| riboflavin | 1.7888 | 0.19553 |
| hypoxanthine | 1.6282 | 0.23352 |
| acetyllysine | 1.5539 | 0.5435 |
| NAD | 1.5512 | 0.47123 |
| taurine | 1.5405 | 0.21332 |
| thiamine | 1.4869 | 0.47274 |
| aspartate | 1.3202 | 0.68641 |
| putrescine | 1.3107 | 0.64286 |
| kynurenine | 1.2857 | 0.56968 |
| dAMP | 1.2535 | 0.61138 |
| thymidine | 1.2419 | 0.6972 |
| ornithine | 1.2218 | 0.70841 |
| phenylalanine | 1.2154 | 0.49828 |
| AMP | 1.2057 | 0.69525 |
| S-adenosylhomocysteine | 1.1992 | 0.77036 |
| acetylcarnitine | 1.1403 | 0.68641 |
| trimethyllysine | 1.1395 | 0.83403 |
| carnitine-C8 | 1.1074 | 0.78839 |
| carnitine-C3 | 1.0818 | 0.83403 |
| asparagine | 1.0678 | 0.72161 |
| choline | 1.0661 | 0.83403 |
| malate | 1.0497 | 0.78839 |
| glycerophosphorylcholine | 1.0439 | 0.9381 |
| 1-methylhistidine | 1.0248 | 0.9381 |
| nicotinamide | 1.0018 | 0.99511 |
| glyoxylate | 0.98478 | 0.9381 |
| dimethylglycine | 0.97783 | 0.91723 |
| glycine | 0.94707 | 0.91453 |
| succinate | 0.94473 | 0.83403 |
| alanine | 0.92949 | 0.78839 |
| carnitine-C6 | 0.92856 | 0.83403 |
| indole | 0.92843 | 0.83403 |
| tryptophan | 0.92275 | 0.80122 |
| urea | 0.90704 | 0.66141 |
| Guanidoacetic acid | 0.88659 | 0.70463 |
| histidine | 0.86073 | 0.67732 |
| valine | 0.8468 | 0.66141 |
| tyrosine | 0.82787 | 0.47274 |
| leucine | 0.82491 | 0.29642 |
| citrulline | 0.82483 | 0.44062 |
| S-lactoylglutathione | 0.81622 | 0.78839 |
| guanosine | 0.81517 | 0.55117 |
| pyroglutamic acid | 0.81294 | 0.61138 |
| GMP | 0.81159 | 0.64286 |
| 3-hydroxybutyrate | 0.80538 | 0.72186 |
| hydroxyphenylpyruvate | 0.798 | 0.26547 |
| glycerate | 0.77694 | 0.66141 |
| phenyllactic acid | 0.77196 | 0.02971 |
| homoserine/threonine | 0.7596 | 0.44062 |
| methionine | 0.74125 | 0.28847 |
| carnitine | 0.73503 | 0.38386 |
| cADP-ribose | 0.73299 | 0.12096 |
| O-acetylserine | 0.72801 | 0.19553 |
| homocysteine | 0.72727 | 0.16015 |
| methylglyoxal | 0.72483 | 0.08875 |
| creatine | 0.72291 | 0.24821 |
| fumarate | 0.7092 | 0.17141 |
| lactate | 0.70716 | 0.13819 |
| proline | 0.69532 | 0.27038 |
| alpha-ketoisovaleric acid | 0.6943 | 0.14034 |
| cystathionine | 0.6937 | 0.56124 |
| UMP | 0.67863 | 0.13819 |
| carbamoylphosphate | 0.67623 | 0.33231 |
| N-acetylglucosamine phosphate | 0.65886 | 0.05477 |
| carnitine-C4 | 0.63354 | 0.52908 |
| CMP | 0.60248 | 0.11112 |
| orotate | 0.60141 | 0.15634 |
| pipecolic acid | 0.6 | 0.05259 |
| fructose | 0.59758 | 0.09166 |
| adenine | 0.59213 | 0.03863 |
| hydroxyproline | 0.59052 | 0.00051 |
| GSH | 0.58564 | 0.12364 |
| pantothenic acid | 0.57614 | 0.11592 |
| cytidine | 0.54462 | 0.05231 |
| phospho-hydroxybenzoate | 0.53605 | 0.31067 |
| phosphocholine | 0.53561 | 0.06755 |
| propionylcholine | 0.53061 | 0.13303 |
| 1-methyladenosine | 0.52411 | 0.00529 |
| glutamate | 0.48917 | 0.01647 |
| N-acetylaspartate | 0.48911 | 0.15634 |
| hydroxyglutarate | 0.48629 | 0.01468 |
| acetylcholine | 0.48281 | 0.03065 |
| shikimic acid | 0.46778 | 0.05604 |
| phosphocreatine | 0.46674 | 0.13819 |
| carnitine-C5 | 0.45886 | 0.19875 |
| alpha-ketoglutarate | 0.4554 | 0.08972 |
| arginine | 0.44217 | 0.02915 |
| 2-deoxycytidine | 0.43995 | 0.23352 |
| uracil | 0.43712 | 0.01468 |
| 5-aminolevulinic acid | 0.436 | 0.00012 |
| nicotinate | 0.4316 | 0.19553 |
| lysine | 0.40191 | 6.12E-05 |
| 1-methylnicotinamide | 0.39599 | 0.33556 |
| N,N-dimethylarginine | 0.38777 | 0.00093 |
| carnitine-C14 | 0.3696 | 0.24821 |
| myo-inositol | 0.34547 | 0.13347 |
| creatinine | 0.29845 | 0.00047 |
| ascorbic acid | 0.25524 | 1.57E-06 |
| XMP | 0.15598 | 0.06755 |
| carnitine-C12 | 0.15514 | 0.09166 |
| ADP | 0.071143 | 2.54E-07 |