Extended data table 2.
Fold change and statistical significance corrected for multiple comparisons of metabolites detected by LC-MS/MS in the experiment shown in Extended data figure 2b.
| Metabolite | Fold Change Metastasis/SQ Tumor | FDR |
|---|---|---|
| citraconic acid/ketohexanoic acid | 34.483 | 0.45284 |
| carnitine-C18 | 10.963 | 0.02495 |
| NADP | 10.741 | 0.02463 |
| adenosine 5-diphosphoribose | 6.9242 | 0.01199 |
| carnitine-C16 | 4.962 | 0.03569 |
| hypoxanthine | 4.8303 | 0.01049 |
| pyridoxamine | 4.7958 | 0.02923 |
| betaine | 4.7812 | 0.03627 |
| S-adenosylhomocysteine | 4.3483 | 0.01917 |
| gluconate | 4.2564 | 0.03675 |
| xanthine | 4.1876 | 0.00192 |
| GSSG | 4.0565 | 0.00339 |
| AICAR | 3.8575 | 0.02826 |
| xanthosine | 3.7994 | 0.07897 |
| adenosine | 3.555 | 0.00983 |
| uridine | 3.497 | 9.33E-05 |
| glutamine | 3.318 | 0.01391 |
| aconitate | 3.2415 | 0.04627 |
| sedoheptulose 7-phosphate | 2.9576 | 0.19981 |
| NAD | 2.9139 | 0.00151 |
| riboflavin | 2.8081 | 0.0222 |
| adenosine | 2.7184 | 0.00181 |
| guanosine | 2.4328 | 0.01321 |
| ZMP | 2.4059 | 0.12097 |
| inosine | 2.3785 | 0.14043 |
| IMP | 2.3314 | 0.01049 |
| deoxyinosine | 2.2956 | 0.20059 |
| uridine | 2.2759 | 0.01549 |
| SAICA | 2.0448 | 0.13492 |
| malate | 1.9365 | 1.81E-06 |
| aminoadipic acid | 1.9042 | 0.01321 |
| carnitine-C8 | 1.8744 | 0.0222 |
| kynurenine | 1.869 | 0.00672 |
| dAMP | 1.802 | 0.00099 |
| fructose 6-phosphate | 1.7965 | 0.26537 |
| thymidine | 1.6716 | 0.27532 |
| cADP-ribose | 1.5868 | 0.0663 |
| cytidine | 1.5195 | 0.21432 |
| carnitine-C6 | 1.512 | 0.08539 |
| S-lactoylglutathione | 1.46 | 0.6708 |
| glycerol 3-phosphate | 1.4129 | 0.42166 |
| 7-methylguanosine | 1.4076 | 0.55385 |
| glyoxylate | 1.3983 | 0.00203 |
| S-adenosylmethionine | 1.3577 | 0.15136 |
| glycerophosphorylcholine | 1.335 | 0.16611 |
| tryptophan | 1.318 | 0.19633 |
| 1-methyladenosine | 1.2813 | 0.03412 |
| AMP | 1.2804 | 0.43896 |
| citrate | 1.2214 | 0.67146 |
| nicotinamide | 1.2063 | 0.62079 |
| succinate | 1.196 | 0.50829 |
| hydroxyphenylpyruvate | 1.1937 | 0.26901 |
| phenylalanine | 1.1838 | 0.1462 |
| carnitine-C3 | 1.1524 | 0.54363 |
| tyrosine | 1.1166 | 0.50877 |
| methionine | 1.0869 | 0.70454 |
| 2-aminooctanoic acid | 1.0803 | 0.71185 |
| adenine | 1.0676 | 0.74371 |
| asparagine | 1.0509 | 0.69494 |
| pipecolic acid | 1.0216 | 0.96295 |
| thiamine | 1.0179 | 0.97565 |
| ribose 5-phosphate | 1.0132 | 0.97843 |
| homocysteic acid | 1.0076 | 0.97843 |
| fumarate | 1.0022 | 0.9897 |
| indole | 1.0017 | 0.9897 |
| pantothenic acid | 0.97947 | 0.9674 |
| homocysteine | 0.97252 | 0.96295 |
| Guanidoacetic acid | 0.97007 | 0.79908 |
| valine | 0.94431 | 0.69728 |
| orotate | 0.93458 | 0.90099 |
| methionine sulfoxide | 0.90754 | 0.71378 |
| citrulline | 0.90545 | 0.69494 |
| leucine | 0.90323 | 0.39527 |
| GSH | 0.88817 | 0.69787 |
| S-methyl-5-thioadenosine | 0.87643 | 0.60788 |
| putrescine | 0.87293 | 0.3561 |
| cysteine | 0.86437 | 0.7895 |
| 3-hydroxybutyrate | 0.86329 | 0.5511 |
| N-acetylaspartate | 0.78325 | 0.48791 |
| serine | 0.78075 | 0.79908 |
| alanine | 0.76685 | 0.11668 |
| carnitine-C14 | 0.76026 | 0.70454 |
| GMP | 0.74002 | 0.18657 |
| histidine | 0.72959 | 0.0396 |
| O-acetylserine | 0.72727 | 0.01269 |
| glutamate | 0.72558 | 0.14273 |
| acetylcarnitine | 0.68306 | 0.00192 |
| 2-deoxycytidine | 0.67868 | 0.29585 |
| ascorbic acid | 0.67473 | 0.28456 |
| carnitine-C12 | 0.67254 | 0.5056 |
| lactate | 0.65954 | 0.00047 |
| choline | 0.65842 | 0.00389 |
| acetylcholine | 0.6573 | 0.13515 |
| creatinine | 0.6543 | 0.16525 |
| y-aminobutyric acid | 0.64139 | 0.2191 |
| glucose/fructose | 0.63849 | 0.00925 |
| homoserine/threonine | 0.62876 | 0.02462 |
| dimethylglycine | 0.62167 | 0.00068 |
| carnitine-C4 | 0.59432 | 0.16312 |
| N-acetylglucosamine phosphate | 0.59273 | 0.00095 |
| glucuronate | 0.57813 | 0.00338 |
| UMP | 0.57702 | 0.0163 |
| uridine 5-diphosphoglucuronic acid | 0.57518 | 0.02632 |
| phenyllactic acid | 0.57402 | 0.00024 |
| N,N-dimethylarginine | 0.5534 | 0.00047 |
| propionylcholine | 0.55055 | 0.00853 |
| allantoin | 0.54186 | 2.44E-05 |
| urea | 0.52852 | 7.29E-07 |
| 1 -methylnicotinamide | 0.51941 | 0.02008 |
| 5-aminolevulinic acid | 0.51688 | 8.12E-05 |
| deoxyribose phosphate | 0.50607 | 0.01321 |
| uracil | 0.50113 | 0.06104 |
| carnitine | 0.49567 | 1.66E-07 |
| taurine | 0.46303 | 2.17E-05 |
| cytosine | 0.45951 | 6.21E-07 |
| proline | 0.4591 | 4.23E-06 |
| carnitine-C5 | 0.44249 | 0.00483 |
| ornithine | 0.43836 | 0.00505 |
| 1-methylhistidine | 0.4023 | 2.31E-06 |
| uracil | 0.3904 | 0.01116 |
| creatine | 0.37961 | 1.26E-07 |
| trimethyllysine | 0.37893 | 7.58E-05 |
| arginine | 0.36929 | 0.00047 |
| CMP | 0.36814 | 3.24E-09 |
| phosphocholine | 0.36461 | 7.43E-09 |
| alpha-ketoglutarate | 0.35719 | 0.02197 |
| spermidine | 0.35496 | 0.03329 |
| acetyllysine | 0.35375 | 3.01E-05 |
| phosphocreatine | 0.34497 | 0.00048 |
| agmatine | 0.32422 | 8.26E-06 |
| hydroxyglutarate | 0.30783 | 3.24E-09 |
| lysine | 0.27436 | 3.91E-10 |
| phosphoenolpyruvic acid | 0.27364 | 1.99E-08 |
| XMP | 0.2693 | 4.33E-05 |
| cystathionine | 0.26823 | 0.02462 |
| glycine | 0.24469 | 3.32E-09 |
| carbamoylphosphate | 0.17283 | 8.74E-09 |
| myo-inositol | 0.14292 | 5.08E-07 |
| cadaverine | 0.06894 | 0.09355 |
| nicotinate | 0.066878 | 0.12347 |