Extended data table 4.

Fold increase in metastatic nodules as compared to subcutaneous tumours of transcripts involved in antioxidant responses and NADPH generation.Data are based on RNAseq analysis of two subcutaneous tumours and two metastatic nodules for each of M405 and M481.

Gene Name	Gene	Metastatic/Subcutaneous (Fold Change)	p-value*
GCLC	Glutamate-cysteine ligase (catalytic subunit)	1.20	0.560
GCLM	Glutamate-cysteine ligase (modifier subunit)	0.86	0.300
GSS	Glutathione synthase	0.90	0.240
SOD1	Superoxide disumutase 1	1.09	0.355
SOD2	Superoxide dismutase 2	0.86	0.454
SOD3	Superoxide dismutase 3	0.64	0.189
CAT	Catalase	1.09	0.548
GPX1	Glutathione Peroxidase 1	1.30	0.117
GPX2	Glutathione Peroxidase 2	1.00	0.998
GPX3	Glutathione Peroxidase 3	0.40	0.048
GPX4	Glutathione Peroxidase 4	1.07	0.459
GPX7	Glutathione Peroxidase 7	0.83	0.183
GPX8	Glutathione Peroxidase 8	0.87	0.631
GSR	Glutathione Reductase	1.12	0.372
HMOX1	Heme Oxygenase 1	0.86	0.186
HMOX2	Heme Oxygenase 2	1.41	0.008
TXN	Thioredoxin 1	1.16	0.297
TXN2	Thioredoxin 2	1.15	0.480
TXNRD1	Thioredoxin redutase 1	0.97	0.859
TXNRD2	Thioredoxin redutase 2	0.91	0.701
TXNRD3	Thioredoxin redutase 3	1.15	0.176
PRDX1	Peroxiredoxin 1	1.67	0.334
PRDX2	Peroxiredoxin 2	0.94	0.289
PRDX3	Peroxiredoxin 3	1.31	0.013
PRDX4	Peroxiredoxin 4	1.13	0.075
PRDX5	Peroxiredoxin 5	1.28	0.032
PRDX6	Peroxiredoxin 6	1.05	0.172
NFE2L2	Nuclear factor, erythroid 2-like 2	0.90	0.106
G6PD	Glucose-6-phosphate Dehydrogenase	2.20	0.156
PGD	Phosphogluconate dehydrogenase	0.98	0.758
ME2	Malic Enzyme 2	1.05	0.865
CBS	Cystathione beta Synthase	1.20	0.469

^*based on Bonferroni correction for multiple comparisons a p-value of 0.0016 would be considered statistically significant in this analysis