Figure 4.

A: MTR map. B: Cystic probability map displaying cystic regions in red. Microcysts (subvoxel) appear green in this representation due to voxel partial volume effects. C: Fibrotic probability map showing more fibrotic regions in green and red. For the corresponding panels, the color bar indicates the probability (or volume fraction) of each voxel to be cystic or fibrotic, where blue indicates 0% and red indicates 100%. D: MTR histogram and GMM classification overlaid. Cystic tissue is conveyed by the green component, parenchyma is conveyed by the red component, and fibrotic tissue is conveyed by the blue component. E: Corresponding histological slice stained with hematoxylin and eosin. F: Picrosirius red staining. The application of a three‐tissue GMM approach to delineate both cystic (green) and fibrotic (blue) from normal healthy parenchyma tissue (red) was achievable in more severe cases such as this example (panel D). The posterior probability maps for both cysts (comparing panels B–E) and fibrotic tissue (comparing panels C–F) correspond closely to the ground truth observed in the histological slides. Scale bar = 1 mm.