Table 4.

Association between history of gestational diabetes and diabetes by randomization arm, before and after adjustment for baseline and change in biomarker levels between baseline and year 1, hazard ratios and 95% CIs shown.

	Hazard ratio (95% CI)
	Intensive lifestyle change	Metformin	Placebo
Unadjusted association between history of gestational diabetes and diabetes	1.53 (0.95, 2.48)	1.00 (0.62, 1.61)	1.65 (1.16, 2.34)
Adjusted for baseline log CRP, change in log CRP, age (years), race (white vs. non-white), weight (kg), and change in weight	1.26 (0.75, 2.13)	1.20 (0.71, 2.04)	1.79 (1.22, 2.64)
Adjusted for baseline fibrinogen, change in fibrinogen, age (years), race (white vs. non-white), weight (kg), and change in weight	1.26 (0.75, 2.13)	1.14 (0.67, 1.93)	1.71 (1.16, 2.51)
Adjusted for baseline adiponectin, change in adiponectin, age (years), race (white vs. non-white), weight (kg), and change in weight	1.25 (0.71, 2.23)	0.97 (0.53, 1.78)	1.95 (1.31, 2.90)
Adjusted for baseline tissue plasminogen-activator antigen, change in tissue plasminogen-activator antigen, age (years), race (white vs. non-white), weight (kg), and change in weight	1.24 (0.74, 2.09)	1.04 (0.60, 1.81)	1.77 (1.20, 2.60)

Referent group is women without history of gestational diabetes