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. 2015 Nov 9;8:543–554. doi: 10.2147/DMSO.S90662

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© 2015 Seufert. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Percent change in body weight as a concomitant effect of SGLT2 inhibition with canagliflozin 100 mg and 300 mg in a direct comparison with placebo, glimepiride, and sitagliptin: examples from clinical Phase III trials on canagliflozin monotherapy, dual combination therapy, triple combination therapy, and in combination with insulin.

Notes: *P<0.001 vs PBO. **P<0.0001 vs GLIM. ***P<0.001 vs SITA.

Abbreviations: SGLT2, sodium glucose cotransporter 2; CANA, canagliflozin; PBO, placebo; GLIM, glimepiride; SITA, sitagliptin; LS, least squares; MET, metformin; SU, sulfonylurea; OAD, oral antidiabetic.