Table 1.
Selected instruments and subdomains measured for each of the four domains of health status
| COPD |
| 1) Main domain physiological functioning |
| • History: eg, smoking habit, exacerbations, comorbidity |
| • BMI |
| • Capillary blood gases |
| • Spirometry and flow volume curve, reversibility |
| • Metronome-paced hyperventilation (MPH) test |
| • Chest X-ray (age >40 years) |
| 2) Main domain symptoms |
| • Medical Research Council (MRC) dyspnea scale |
| • CCQ: subdomain symptoms |
| • NCSI: subdomain dyspnea and fatigue |
| 3) Main domain functional limitations |
| • CCQ: subdomain functional state |
| • Dynaport triaxial accelerometer: actual activity level |
| • NCSI: subdomains subjective and behavioral impairment |
| 4) Main domain quality of life |
| • CCQ: subdomain emotions |
| • NCSI: subdomains general quality of life, health-related quality of life, and satisfaction with relations |
| Asthma |
| 1) Main domain physiological functioning |
| • History: eg, smoking habit, exacerbations, comorbidity |
| • BMI |
| • Capillary blood gases |
| • Spirometry and flow volume curve, reversibility |
| • Metronome-paced hyperventilation (MPH) test |
| • Chest X-ray |
| • Allergic assessment (RAST and blood eosinophils and total IgE) |
| • Nitric oxide (FeNO) |
| 2) Main domain symptoms |
| • ACQ |
| • Medical Research Council (MRC) dyspnoea scale |
| • NCSI: subdomains dyspnea and fatigue |
| 3) Main domain functional limitations |
| • ACQ |
| • Dynaport triaxial accelerometer: actual activity level |
| • NCSI: subdomains subjective and behavioral impairment |
| 4) Main domain quality of life |
| • NCSI: subdomains general quality of life, health-related quality of life, and satisfaction with relations |
Abbreviations: RAST, radioallegrosorbent test; IgE, Immunoglobulin E; CCQ, Clinical COPD Questionnaire; NCSI, Nijmegen Clinical Screening Instrument; BMI, body mass index; ACQ, Asthma Control Questionnaire.