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. 2015 Nov 6;10:1825–1837. doi: 10.2147/CIA.S93819

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© 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The schematic diagram illustrates the possible neuroprotective pathways in the brain under oral B401 treatment. Oral B401 treatment may improve neuroprotection in R6/2 mice via enhancing anti-oxidative stress (marked by SOD2) and anti-apoptosis (marked by Bcl-2), while suppressing mutant huntingtin aggregation, ROS production, ER stress-related apoptosis (marked by calpain), and mitochondrial dysfunction-related apoptosis (marked by Bax and caspase 3) in the brain.

Abbreviations: Bax, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma 2; ER, endoplasmic reticulum; mHtt, mutant huntingtin; ROS, reactive oxygen species; SOD2, superoxide dismutase 2.