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. 2015 Nov 6;10:1825–1837. doi: 10.2147/CIA.S93819

Figure 6.

Figure 6

Expressions of anti-oxidative stress-related SOD2 in the brain tissue of the R6/2 (HD) mice were enhanced under oral B401 treatment.

Notes: (A) IHC staining shows that the expressions of SOD2 in the striatum, hippocampus, and medulla of the 10-week-old R6/2 mice given the oral B401 treatment were obviously more intense than those given the sham treatment but were obviously weaker than their WT. Scale bars: 30 µm. Western blotting analysis shows the following: (Ba) expression levels of SOD2 in whole brain tissue of the 10-week-old R6/2 mice given both oral B401 and sham treatments, and their WT and (Bb) quantified brain SOD2 levels of the 10-week-old R6/2 mice were significantly lower than their WT and significantly higher under oral B401 treatment. The number of R6/2 mice under oral B401 and sham treatments and their WT was six for each group. Values are mean ± SEM (**P<0.01, two-way ANOVA followed by a Student–Newman–Keuls multiple comparison posttest).

Abbreviations: HD, Huntington’s disease; IHC, immunohistochemistry; SOD2, superoxide dismutase 2; WT, wild-type littermate; ANOVA, analysis of variance; SEM, standard error of the mean.