Table 1.
Action Potential Parameters of Single Spontaneously Active Cardiomyocytes
| Vehicle (n = 12) | T3+IGF-1 (n = 15) | T3+IGF-1+Dex (n = 33) | TID+SGKi (n = 16) | |
|---|---|---|---|---|
| MDP (mV) | –66.9 ± 1.2 | –71.5 ± 0.9a | –74.2 ± 0.8a | –74.2 ± 1.1a |
| dV/dtmax (V/s) | 15.8 ± 2.2 | 21.5 ± 4.9 | 58.9 ± 4.6a | 36.5 ± 5.6 |
| APA (mV) | 97 ± 2 | 104 ± 2a | 112 ± 2a | 114 ± 2a |
| APD50 (ms) | 110 ± 11 | 98 ± 12 | 104 ± 11 | 97 ± 10 |
| APD90 (ms) | 146 ± 14 | 125 ± 13 | 134 ± 11 | 124 ± 10 |
| Frequency (Hz) | 1.6 ± 0.2 | 2.1 ± 0.2 | 2.5 ± 0.2a | 2.2 ± 0.2 |
| Capacitance (Cm) | 20 ± 3 | 17 ± 1 | 25 ± 2 | 24 ± 3 |
Data are mean ± SEM; TID+SGKi = T3+IGF-1+Dex+GSK650394, n = number of cells; MDP, maximal diastolic potential; dV/dtmax, maximal upstroke velocity; APA, action potential amplitude; APD50 and APD90, action potential duration at 50% and 90% repolarization, respectively.
a
p < 0.05 compared to vehicle. One-way ANOVA with a Tukey post-test.