Figure 6.

Determinants of Specificity in the Human SH2 Domain

(A) Mesh representation of the SH2 domain, including its secondary structure in cartoon representation and a bound peptide substrate colored in orange. Positions predicted as DoS by KINspect (i.e., residues with a KINspect score higher than 0.9) are highlighted in cyan.

(B–I) As in the case of the kinase domain, longitudinal (B–E) and transversal (F–I) slices were taken through the SH2 domain at the planes indicated in the inset in (A). For a dynamic visualization of this structure, please refer to Movie S2. The structure used is that of SAP in complex with SLAM peptide (PDB ID: 1D4T; Poy et al., 1999).