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. 2015 Oct 19;7(11):1480–1502. doi: 10.15252/emmm.201505246

Figure EV5. Down-regulation of NGK2D on CD8+ T cells in response to the MICA-129Met and MICA-129Val isoforms.

Figure EV5

  1. Purified CD8+ T cells were analyzed by flow cytometry for NKG2D expression as illustrated here. The MFI for NKG2D and the percentage of NKG2D+CD8+ T cells are indicated.
  2. The NK cells were subsequently co-cultured with an L-con, L-MICA-129Met, or L-MICA-129Val clone (the MFI values for MICA on these clones are indicated above the histograms in brackets). NKG2D expression was determined as illustrated in (A) after 4 and 24 h. The MFI for NKG2D and the percentages of NKG2D+CD8+ T cells are indicated.