Figure 4. Mutant HTT protein forms age-dependent aggregates in the fly brain.
Confocal images of adult brains expressing HTTex1 with a 46 glutamine tract (HTTex1-Q46) at (A) day 2 and (B) day 30. (C and D) High-magnification views of the regions highlighted above. HTTex1-Q46 protein is evenly dispersed in mushroom bodies and other structures in young brains but forms prominent aggregates by day 30.