Table 3.
Task effect: fMRI results for main effect of condition and main effect of group.
| Main effect of Condition | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Mask | Voxels | Volume (uL) | x | y | z | L / R | BA | Center of mass | Result |
| Whole brain | 602 | 38528 | −47 | −7 | 26 | L | Precentral Gyrus | Plug>Ant | |
| Whole brain | 585 | 37440 | 49 | −8 | 26 | R | Precentral Gyrus | Plug>Ant | |
| Whole brain | 417 | 26688 | −10 | −70 | −17 | L | Declive | Plug>Ant | |
| Whole brain | 363 | 23232 | 1 | −17 | 58 | R | Medial Frontal Gyrus | Plug>Ant | |
| Whole brain | 312 | 19968 | 29 | −42 | 13 | R | Caudate | Ant>Plug | |
| rROI | 118 | 7552 | 39 | 0 | 12 | R | Anterior & Posterior Insula | Plug>Ant | |
| rROI | 89 | 5696 | −37 | 2 | 9 | L | Anterior & Posterior Insula | Plug>Ant | |
| Whole brain | 85 | 5440 | −1 | −14 | −26 | L | Brain | Ant>Plug | |
| Whole brain | 76 | 4864 | −41 | −25 | −9 | L | Parahippocampal Gyrus | Ant>Plug | |
| Whole brain | 49 | 3136 | −26 | −46 | 9 | L | Parahippocampal Gyrus | Plug>Ant | |
| Whole brain | 32 | 2048 | 17 | 5 | −2 | R | Lentiform Nucleus | Plug>Ant | |
| Whole brain | 27 | 1728 | −5 | −50 | 58 | L | Precuneus | Plug>Ant | |
| Whole brain | 19 | 1216 | −34 | 37 | 36 | L | Middle Frontal Gyrus | Plug>Ant | |
| Whole brain | 19 | 1216 | −9 | −12 | 43 | L | Paracentral Lobule | Plug>Ant | |
| Whole brain | 17 | 1088 | −7 | 61 | −2 | L | Superior Frontal Gyrus | Plug>Ant | |
| Whole brain | 16 | 1024 | 48 | −48 | 21 | R | Superior Temporal Gyrus | Plug>Ant | |
| Whole brain | 14 | 896 | −21 | 0 | 38 | L | Cingulate Gyrus | Ant>Plug | |
| Whole brain | 13 | 832 | −56 | −45 | −12 | L | Middle Temporal Gyrus | Plug>Ant | |
| Whole brain | 12 | 768 | −31 | 52 | −3 | L | Middle Frontal Gyrus | Plug>Ant | |
| Whole brain | 12 | 768 | −2 | −95 | 2 | L | Cuneus | Ant>Plug | |
| Whole brain | 12 | 768 | −13 | −17 | 9 | L | Thalamus | Plug>Ant | |
| Main Effect of Group | |||||||||
| Whole brain | 12 | 768 | −27 | −5 | 33 | L | Precentral Gyrus | CON>SUD | |
Plug = breathing load; Ant = Anticipation; CON = Control group; SUD = Substance Use Disorder group; L = left hemisphere; R = right hemisphere; rROI = Restricted ROI based on hypothesis; Talairach coordinates reflect center of mass. Regions reflect significant clusters of at least 12 contiguous voxels (whole brain; 768µL) or 6 contiguous voxels (rROI; 384µL) meeting the F(1,31)=4.16, p<.05 threshold corrected for multiple comparisons via AlphaSim.