Table 4.
fMRI results for interaction effect of group by condition.
| Mask | Voxels | Volume (uL) |
x | y | z | L/R | Center of mass | BA | Ant | Plug |
|---|---|---|---|---|---|---|---|---|---|---|
| Whole brain | 36 | 2304 | 45 | −7 | 17 | R | Posterior Insula | BA 13 | CON>SUD | SUD>CON |
| Whole brain | 26 | 1664 | −33 | 43 | 25 | L | Middle Frontal Gyrus | BA 10 | CON=SUD | SUD>CON |
| Whole brain | 22 | 1408 | −24 | −21 | −22 | L | Parahippocampal Gyrus | BA 35 | CON>SUD | CON=SUD |
| Whole brain | 20 | 1280 | −30 | 5 | −27 | L | Uncus | BA 38 | CON=SUD | SUD>CON |
| Whole brain | 15 | 960 | −59 | −36 | −11 | L | Middle Temporal Gyrus | BA 21 | CON=SUD | SUD>CON |
| Whole brain | 14 | 896 | −31 | 24 | 10 | L | Anterior Insula | BA 13 | CON=SUD | SUD>CON |
| Whole brain | 13 | 832 | −45 | 4 | −7 | L | Superior Temporal Gyrus | BA 38 | CON>SUD | CON=SUD |
| Whole brain | 13 | 832 | 41 | 25 | 10 | R | Inferior Frontal Gyrus | BA 13 | CON=SUD | SUD>CON |
| rROI | 8 | 512 | −45 | 4 | −6 | L | Posterior Insula | BA 38 | CON>SUD | CON=SUD |
L = left hemisphere; R = right hemisphere; Ant = Anticipation; Plug = breathing load; CON = Control group; SUD = Substance Use Disorder group; rROI = Restricted ROI based on hypothesis; Talairach coordinates reflect center of mass; BA = Brodmann Area. Regions reflect significant clusters of at least 12 contiguous voxels (whole brain; 768µL) or 6 contiguous voxels (rROI; 384µL) meeting the F(1,31)=4.16, p<.05 threshold corrected for multiple comparisons via AlphaSim.