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. Author manuscript; available in PMC: 2015 Dec 10.
Published in final edited form as: Sci Transl Med. 2015 Jun 10;7(291):291ra96. doi: 10.1126/scitranslmed.aaa5731

Figure 2. Flt3/ITD-SmoM2 mice develop rapidly fatal AML.

Figure 2

(A) Kaplan Meier survival curve of transgenic animals after poly(I:C) induction. Statistical significance determined by log-rank (Mantel-Cox) test comparing Flt3/ITD and Flt3/ITD-SmoM2 animals. (B) White blood cell counts at 3 months after the completion of poly(I:C) treatment. Data represent mean ± SD. (C) Wright-Giemsa staining of peripheral blood smears. (D) FACS analysis of peripheral blood cells. Bar graph represents percentage of Mac1+Gr1+ cells (n=5–7 per genotype). Data represent mean ± SD. (E) FACS analysis of bone marrow cells. Bar graph depicts bone marrow cellularity and percentage of Gr1+cKit+ cells (n=3–7 per genotype). Data represent mean ± SD. (F) Spleen weights and representative spleen sizes. Data represent mean ± SD. (G) Hematoxylin and eosin staining of bone marrow and spleen sections. RP: red pulp, WP: white pulp.