Fig 2.

Sample PRM snapshots for a patient with confirmed pseudoprogression (top) and a patient with true tumor progression without pseudoprogression (bottom) give a spatiotemporal reference to tumor characterization. ADC maps are coregistered onto a common space, and voxelwise subtraction is calculated between each subsequent time point and the baseline scan. Green voxels indicate no significant change above or below the predefined threshold of ±0.4 mm²/s. Red voxels show a significant increase in ADC, and blue voxels, a decrease in ADC compared with the baseline. There is evidence of spatial heterogeneity of diffusion within the brain stem tumor of both patients.