Table I.
Comparison of baseline patient characteristics between high-risk and standard-risk MM patients.
| Characteristic | High-risk MM*, n (%) or median (range) | Standard-risk MM, n (%) or median (range) | p-value |
|---|---|---|---|
| Total number of patients | 74 (11) | 596 (89) | |
|
| |||
| Age, years | 58 (40–73) | 58 (31–80) | 0.88 |
|
| |||
| Sex | |||
| Male | 53 (72) | 335 (56) | 0.003 |
|
| |||
| Race | |||
| White | 52 (70.3) | 394 (66.1) | |
| Black | 9 (12.2) | 99 (16.6) | 0.61 |
| Other | 12 (16.2) | 99 (16.6) | |
| Missing Data | 1 (1.4) | 4 (0.7) | |
|
| |||
| Histologic features | |||
| Immunoglobulin G | 37 (50) | 339 (57) | |
| Immunoglobulin A | 17 (23) | 123 (21) | 0.03 |
| Light chain only | 10 (13.5) | 96 (16) | |
| Other | 10 (13.5) | 38 (6) | |
|
| |||
| Durie-Salmon stage | |||
| I | 5 (7) | 111 (18.6) | |
| II | 35 (47) | 237 (39.8) | 0.03 |
| III | 32 (43) | 225 (37.8) | |
| Missing data | 2 (3) | 23 (3.9) | |
|
| |||
| Bone marrow plasma cell percentage | 52 (0–95) | 29 (0–98) | <0.001 |
| Hemoglobin, g/dl | 10 (6–15) | 11.4 (6–17) | 0.003 |
| Lactate dehydrogenase, unit/l | 344 (44–1365) | 369 (51–1950) | 0.04 |
| Calcium, mg/dl | 9.5 (7–17) | 9.4 (7–18) | 0.06 |
| Creatinine, mg/dl | 1.2 (1–15) | 1.1 (0–21) | 0.08 |
| Beta-2-microgloobulin, mg/l | 3.9 (2–35) | 3.1 (1–47) | 0.21 |
| Immunoglobin G, mg/dl | 839 (168–10310) | 1634 (10–14946) | 0.15 |
| Immunoglobin A, mg/dl | 50 (6–8089) | 65 (2–9818) | 0.93 |
| Immunoglobin M, mg/dl | 21 (3–8050) | 21 (1–10400) | 0.19 |
| Bence Jones protein, mg/dl | 1.01 (0–20) | 0.25 (0–37) | 0.08 |
| Serum M-protein (g/dL) | 3 (0–8) | 2.60 (0–13) | 0.5 |
*
Based on cytogenetics or FISH at any time before autologous hematopoietic stem cell transplantation.