Table 1 ***.
Subject Characteristics
| Discovery Cohort | Replication Cohort** | |||||
|---|---|---|---|---|---|---|
| Characteristic | No ROP (n=264) | Non-Severe ROP (n=467) | Severe ROP (n=126) | No ROP (n=331) | Non-Severe ROP (n=195) | Severe ROP (n=14) |
| Gestational Age in Weeks (SD) | 27.1 (1.9) | 25.7 (1.7) | 24.5 (1.2) | 28.7 (1.9) | 26.2 (2.1) | 24.4 (1.0) |
| Birth Weight in Grams (SD) | 823.6 (126.0) | 758 (133.0) | 697 (125.0) | 1242 (356.0) | 904 (291.0) | 678 (167.0) |
| Small for Gestational | 64 (24.3) | 55 (12.1) | 6 (4.8) | 36 (10.9) | 23 (11.8) | 3 (21.4) |
| Age, number (%) | ||||||
| Male, number (%) | 113 (43.0) | 222 (48.8) | 62 (50.0) | 195 (58.9) | 109 (50.0) | 8 (57.1) |
| Mean Days in Ventilation (SD) | 8.2 (9.2) | 17.5 (10.2) | 25.4 (5.7) | 13.7 (18.5) | 41.8 (32.2) | 76.3 (24.7) |
| Occurrence of Seizures, number (%) | 13 (4.9) | 43 (9.4) | 25 (20.2) | 2 (0.6) | 3 (1.5) | 3 (23.1) |
| Antenatal Steroids, number using (%) | 218 (82.9) | 351 (77.1) | 90 (73.2) | 312 (94.3) | 181 (93.3) | 13 (92.9) |
| Race (self-reported) | ||||||
| Black, number (%) | 136 (51.5) | 219 (46.9) | 60 (47.6) | 32 (9.7) | 155 (71.1) | 10 (71.4) |
| White, number (%) | 122 (46.2) | 240 (51.4) | 65 (51.6) | 256 (77.3) | 19 (8.7) | 1 (7.1) |
| * Other, number (%) | 6 (2.2) | 8 (1.7) | 1 (0.7) | 43 (12.9) | 44 (20.1) | 3 (21.4) |
| Ethnicity | ||||||
| Hispanic, number (%) | 29 (11.0) | 101 (21.6) | 24 (19.0) | 20 (6.0) | 8 (3.7) | 1 (7.1) |
| Non-Hispanic, number (%) | 235 (89.0) | 366 (78.4) | 102 (80.9) | 311 (94) | 210 (96.3) | 13 (92.9) |
*
Other –self report of race other than non-Hispanic White or non-Hispanic Black or Hispanic
**
Four infants with ROP lacked information as to whether treatment was performed and are not included
***
From Hartnett ME et al. Genetic variants associated with severe retinopathy of prematurity in extremely low birth weight infants. Invest Ophthalmol Vis Sci 2014;55:6194–6203.54