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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: J Neurochem. 2015 Jun 18;135(6):1203–1217. doi: 10.1111/jnc.13169

Figure 2. Liraglutide treatment protects neural cells from H2O2-induced cell death.

Figure 2

SH-SY5Y or SH-SY5Y#9 cells were pretreated with a series concentrations (0, 10−9, 10−8, 10−7, 10−6 M) of liraglutide for 1h, then challenged with either 75μM (A), 100 μM (B) or 150 μM (C) H2O2 for 24h before performing an MTS assay to assess cell viabilities. In (A) and (B), H2O2 challenge in the absence of liraglutide resulted in a significant loss of cell viability vs. control cells, which was significantly mitigated by liraglutide (1×10−6 M). In (C), in the absence of liraglutide resulted in a significant loss of cell viability vs. control cells, with all liraglutide + H2O2 challenge groups being no different from the control (unchallenged) group, (*P < 0.05; **P <0.01; ***P < 0.001).