Table 1.

Average loss of contacts with water for residues in the region Gln20-Ile50 for systems that adsorbed at the air-water and surface-water interface (Binding Motif 1), compared to the bulk environment, over the last 10 ns of simulation.

Amino acid type	Air-water (%)	Surface-water (%)
Hydrophobic	34	17
Hydrophobic (large)	36	16
Polar	14	14
Proline	52	20
Aspartic acid	24	29

A contact was defined as a water atom coming within 3 Å of the amino acid group types defined by Livingstone and Barton (1993). A detailed plot can be found in Supplementary Figure 4.