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TNF-α or VEGF-mediated NFκB activation promotes inflammation and opening up of EC junctions leading to increased vascular permeability. Increased VCAM-1 is associated with altered EC function and recruitment of immune cells. We propose (A) Inhibition of SK1. (B) Increased miRNA levels will reduce TNF-α or VEGF-mediated NFκB activation and reduce VCAM-1 expression leading to maintenance or improvement of vascular integrity.
