| Dunn M, et al32Michigan,
USA 2007 |
. Case control |
Assessment of OPG in regulating
mechanically induced bone modeling in a rat model of orthodontic tooth
movement. |
39 male Sprague-Dawley rats » 9
rats without appliances: (3 rats without injections, 3 rats with vehicle
and 3 rats with high-dose OPG) » 30 rats with orthodontic forces: (10
rats with 0.5 mg/Kg OPG-Fc, 10 rats with 5.0 mg/Kg OPG-Fc and 10 rats
with vehicle) |
Local delivery of OPG-Fc inhibits
osteoclastogenesis and tooth movement at targeted dental sites. |
| Keles A, et al31Boston
USA 2007 |
Case control |
Evaluation of the efficacy of
pamidronateversus osteoprotegerin (OPG) in the
inhibition of bone resorption and tooth movement. |
18 C57Bl/6 male mice into 3 groups
of 6 mice: » Control group (vehicle) » 5 mg/kg-1 pamidronate » 10 mg/kg-1
OPG |
OPG results in a more powerful
inhibitor of osteoclast recruitment and activity than pamidronate, with a
reduction of osteoclasts number of 95% and tooth movement of 77%. |
