| De Carlos F, et al
4
Spain, 2006 |
Case control |
Comparison of the effect of
Diclofenac and Rofecoxib on the inhibition of dental movement in
rats. |
42 male Wistar rats in 6
experimental groups: » 3 groups subjected to a 50-g coil-spring
(Diclofenac, Rofecoxib, control) » 3 groups subjected to a 10-g
coil-spring (Diclofenac, Rofecoxib, control) |
Both drugs significantly inhibit
dental movement, partially in the case of Rofecoxib and totally in the
case of Diclofenac. |
| De Carlos F, et al
5
Spain, 2007 |
Case control |
Comparison of the effect of
Rofecoxib, Celecoxib, and Parecoxib on the inhibition of dental movement
in rats. |
28 male Wistar rats in 4 groups
subjected to 50-g force derived from a coil-spring: » 5 rats received
Rofecoxib » 6 rats Celecoxib » 5 rats Parecoxib » 12 control rats |
Rofecoxib inhibit tooth movement
while Celecoxib and Parecoxib do not affect orthodontic movement. |
| Mermut S, et al
34
Ankara, Turkey 2007 |
Case control |
Determination of the effects of
IFN- ɣ on bone during orthodontic tooth movement. |
30 male Sprague Dawley rats in five
groups. (6 rats per group) » 0.01 µL IFN-ɣ dose » 0.02 µL IFN-ɣ dose »
0.05 µL IFN-ɣ dose » vehicle solution control group » only orthodontics
control group |
IFN- ɣ seems involved in bone
remodeling during orthodontic tooth movement, which strongly suppresses
osteoclastogenesis. |
| Gurton AU, et al
33
Ankara, Turkey 2004 |
Case control |
Comparison of the effects of PGI2
and TxA2 analogs and inhibitors on orthodontic tooth movement. |
150 male Sprague-Dawley rats in
five equal groups, subdivided into three subgroups (SGs) depending on the
concentration. » Iloprost (PGI2 analog) » indomethacin (PGI2 inhibitor),
» U 46619 (TxA2 analog), » imidazole (TxA2 inhibitor) » control
group |
Indomethacin and Imidazole decrease
the rate of tooth movement at high concentration, although there is no
statistically significant difference between their inhibitory
effects. |
| Chae HS
35
Seoul, Korea 2011 |
Case control |
Evaluation of the effects of
antioxidants on the expression of pro-inflammatory cytokines in human
periodontal ligament fibroblasts (PDLFs) Evaluation of the effects of
these antioxidants on the rate of orthodontic tooth movement in
rats. |
Two different assessments:
Mechanical compression and induced hypoxia applied to human PDLFs exposed
to 10 nM Resveratrol or 20 nM NAC orthodontic forces applied to 12 rats
in a split-mouth design » 6 rats: experimental side treated with
Resveratrol, contralateral side with vehicle solution » 6 rats:
experimental side treated with NAC, contralateral side with vehicle
solution |
Antioxidants decrease the
expression of pro-inflammatory cytokines in human PDLFs induced by
mechanical compression and hypoxia in vitro. NAC delays
orthodontic tooth movement in rats. Antioxidants may have the potential
to retard orthodontic tooth movement. |
