Figure 1.

Intratumour heterogeneity in the evolution of GB. (A) Phylogenetic reconstruction of a GB case based on copy number alterations. (B) It has been hypothesized that TICs reside in the SEZ and can contribute to tumor maintenance (19). These cells (shown in purple) may be potential new targets for molecular therapies in GB. Also shown is the maintenance of the tumor bulk by cells in the SEZ containing the same mutations as described in the phylogenetic tree, and how current therapies target the tumor bulk (shown in red). (C) combines (A,B) to give an overview of tumor evolution in this case across time and in physical location. The case described in all parts of this diagram and all corresponding genetic information was obtained from Sottoriva et al. (10). (B) is adapted from the review by Goffart et al. (20).