Table 1.

Gene expression in hypothesized glioma subclasses.

Classical	Mesenchymal	Proneural	Neural
chr7 ↑/chr10 – (100%)	NF1 ↓ (53%)	PDGFRA ↑	NEFL
EGFR ↑ (97%)	NF1 ↓/PTEN ↓ (86%)	IDH1	GABRA1
EGFRvIII (55%)	MET	TP53 +/−	SYT1
CDKN2A −/−	CHI3L1	TP53 LOH	SLC12A5
NES ↑/Notch ↑	CD44 ↑/MERTK ↑	chr7 ↑/chr10 – (54%)
SHH signaling ↑	NFκB signaling ↑	OLIG2 ↑ (CDKN1A ↓)
		SOX
		TCF4

The table shows changes in gene expression and LOH/deletions in genes in the four subclasses of glioma proposed by Verhaak et al. (9). The changes in gene expression that are characteristic of each subtype are highlighted in each column, and the percentage of cases that express these changes are present for the most ubiquitously expressed genes.