Fig. 2.

Dynamic changes in the ¹³C signals from rat skeletal muscle after injection of 40 mmol l⁻¹ hyperpolarized [1-¹³C]lactate. (A) Control. (B) 1 h after DCA infusion. Each time course (3 s resolution) is normalized by the peak value of the corresponding [1-¹³C]lactate curve. Relative to the signal intensity of [1-¹³C]lactate, the DCA stimulation of PDH produces a rapid time-dependent change in ¹³C spectra, as noted in dynamics of the alanine, pyruvate and HCO₃⁻ signals.