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Dynamic changes in the 13C signal from rat skeletal muscle after injection of 80 mmol l−1 hyperpolarized [2-13C]pyruvate. (A) Control. (B) 1 h after DCA infusion. Each time course (3 s resolution) is normalized by the peak value of the corresponding [2-13C]pyruvate curve. Relative to the signal intensity of [2-13C]pyruvate, the DCA stimulation of PDH produces a rapid time-dependent change in 13C spectra, as noted in a rapid time-dependent changes of the lactate and ALCAR signals.
